The article deals with the problem of organizing and implementing a system of comprehensive support for children with autism spectrum disorders in the Russian Federation. The purpose of the work is to identify features, trends, directions, risks and benefits of implementing successful regional practices of comprehensive support for children with ASD. The authors analyzed modern domestic and foreign studies, monitoring results, concluded that the effectiveness of the implemented regional models “university (institute) – organizations” dealing with the issues of supporting children with autism spectrum disorders, methods and forms. Difficulties and risks are identified, recommendations are given for the implementation of strategies for their further implementation.